Leukemia begins in the immature cells of the bone marrow in the central cavities of bones. The bone marrow produces all types of blood cells: red blood cells that carry oxygen and other materials to the tissues of the body, white blood cells that fight infection, and platelets that help the blood clot. Hundreds of billions of new blood cells are produced in the bone marrow each day, providing the body with a constant supply of fresh, healthy cells. In a patient with leukemia, many of the white blood cells produced in the bone marrow do not mature normally. These abnormal cells, called leukemic cells, are unable to fight infection the way healthy white cells can. As they accumulate, the leukemic cells also interfere with the production of other blood cells. Eventually, the body has too few red cells for supplying oxygen to the body's tissues, too few platelets for proper clotting and too few healthy white cells for fighting infection. As a result, people with leukemia are at risk for bruising, bleeding and infections.
What are the types of Leukaemia?
The main types of leukemia are myelogenous and lymphocytic, and each type has an acute (rapidly progressing) and a chronic (slowly progressing) form. Acute leukemia mainly affects cells that are immature, or not fully developed, preventing them from maturing and functioning normally. Chronic leukemia develops more slowly, so that the body still has some healthy cells available to fight infection.
- Acute Myeloid Leukemia (AML) - Acute myeloid leukemia is the most common type of leukemia in adults, although it also can occur in children. If untreated, this form of leukemia usually progresses quickly.
- Chronic Myeloid Leukemia (CML) - Chronic myeloid leukemia originates from the presence of a genetic abnormality in blood cells, called the Philadelphia chromosome, and progresses through distinct phases. CML occurs mainly in adults, but a very small number of children also develop this disease.
- Acute Lymphoblastic Leukemia (ALL) - Acute lymphoblastic leukemia is the most common type of leukemia in young children in developed countries, but it also affects adults, especially those ages 65 and older. ALL starts in the inner part of the bones, known as bone marrow, but often moves quickly into the blood.
- Chronic Lymphocytic Leukemia (CLL) - Chronic lymphocytic leukemia usually gets worse slowly. CLL is the second most common form of leukemia in adults and rarely occurs in children. More than half of people diagnosed with CLL are older than 70, and cases rarely occur in individuals younger than 40.
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